Mutagenicity of psoralen epoxides.
نویسندگان
چکیده
a Veterinary Toxicology and Entomology Research Laboratory, Agricultural Research, Science and Education Administration, U.S. Department o f Agriculture, College Station, TX 77840, b Western Regional Research Laboratory, Agricultural Research, Science and Education Administration, U.S. Department o f Agriculture, Berkeley, CA 94710, and c Department o f Entomology, University o f California, Riverside, CA 92502 (U.S.A.)
منابع مشابه
Bacterial mutagenicity and toxicity of cycloaliphatic epoxides.
The mutagenicity of 12 cycloaliphatic epoxides was investigated using the Ames Salmonella assay without the addition of liver homogenate fractions. Base-pair substitution mutagenic activity was detected for 8 members of this series of compounds, confirming our laboratory's previous observations of weak mutagenic response at high dose levels for cis-1,2-disubstituted epoxides. While mutagenicity...
متن کاملMutagenicity of aliphatic epoxides.
The mutagenicity of 17 aliphatic epoxides was determined using the specially constructed mutants of Salmonella typhimurium developed by Ames. The activity of these epoxides together with those reported in the literature as mutagens in strains TA100 and TA1535 depended on the degree of substitution around the oxirane ring. Monosubstituted oxiranes were the most potent mutagens in both strains. 1...
متن کاملUse of 4-(nitrobenzyl)pyridine (4-NBP) to test mutagenic potential of slow-reacting epoxides, their corresponding olefins, and other alkylating agents.
Olefins and their corresponding epoxide derivatives are extensively used in industrial processes. Many epoxides are used as intermediates in organic synthesis as well as in surfactants, fumigants, industrial sterilants, cosmetics, and pharmaceuticals. These compounds pose potential hazards for biological systems where 1,2-epoxides are able to cause adverse biological effects through genetic int...
متن کاملMutagenicity of aromatic glycidyl ethers with Salmonella.
6 aromatic glycidyl ethers containing naphthyl, biphenyl or benzylphenyl substituents were synthesized. These epoxides together with the commercially available compounds 2-biphenylyl glycidyl ether were examined for dose-mutagenicity relationships using the plate incorporation Ames test with Salmonella typhimurium strains TA100 and TA1535. Structure-mutagenicity relationships were further exami...
متن کاملFjord- and bay-region diol-epoxides investigated for stability, SOS induction in Escherichia coli, and mutagenicity in Salmonella typhimurium and mammalian cells.
The fjord-region diol-epoxides of benzo(c)phenanthrene combine high mutagenic and carcinogenic activity with low chemical reactivity. To study whether this is a unique property of these compounds or a more general characteristic of fjord-region diol-epoxides, we have synthesized the anti- and syn-diastereomers of r-9,t-10-dihydroxy-11,12-oxy-9,10,11,12-tetrahydrobenzo(c)chrysene and r-11-t-12-d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Mutation research
دوره 79 1 شماره
صفحات -
تاریخ انتشار 1980